Passage
The Lord Jesus Christ be with thy spirit. Grace be with you. Amen.
The Lord Jesus Christ be with thy spirit. Grace be with you. Amen.
2 Timothy 4:20 Erastus abode at Corinth: but Trophimus have I left at Miletum sick.
2 Timothy 4:21 Do thy diligence to come before winter. Eubulus greeteth thee, and Pudens, and Linus, and Claudia, and all the brethren.
2 Timothy 4:22 The Lord Jesus Christ be with thy spirit. Grace be with you. Amen.
The verse centers on "Spirit", "grace", "lord", "jesus", "christ", and "amen". It is saying that salvation is received as God's gift through faith, so boasting is pushed out by the wording itself.
The prior verse says "Do thy diligence to come before winter...", giving immediate footing for "Spirit" and "grace". In 2 Timothy context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "Spirit" and "grace" with trust shaped by these words, not by a vague optimism outside the passage.