Passage
The Lord be with thy spirit. Grace be with you.
The Lord be with thy spirit. Grace be with you.
2 Timothy 4:20 Erastus remained at Corinth: but Trophimus I left at Miletus sick.
2 Timothy 4:21 Give diligence to come before winter. Eubulus saluteth thee, and Pudens, and Linus, and Claudia, and all the brethren.
2 Timothy 4:22 The Lord be with thy spirit. Grace be with you.
The verse centers on "Spirit", "grace", and "lord". It is saying that salvation is received as God's gift through faith, so boasting is pushed out by the wording itself.
The prior verse says "Give diligence to come before winter Eubulus...", giving immediate footing for "Spirit" and "grace". In 2 Timothy context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "Spirit" and "grace" with trust shaped by these words, not by a vague optimism outside the passage.