Passage
Thou wilt pursue them in anger, and destroy them from under the heavens of Jehovah.
Thou wilt pursue them in anger, and destroy them from under the heavens of Jehovah.
Lamentations 3:64 Thou wilt render unto them a recompense, O Jehovah, according to the work of their hands.
Lamentations 3:65 Thou wilt give them hardness of heart, thy curse unto them.
Lamentations 3:66 Thou wilt pursue them in anger, and destroy them from under the heavens of Jehovah.
The verse centers on "thou", "wilt", "pursue", "anger", "destroy", "under", "heavens", and "jehovah". It is saying that the verse draws attention to "thou" and "wilt", so its meaning should be read from those terms before moving to application.
The prior verse says "Thou wilt give them hardness of heart...", giving immediate footing for "thou" and "wilt". In Lamentations context, the local focus is covenant, worship, and faithfulness.
A plain takeaway is to answer the verse's own emphasis on "thou" and "wilt" with trust shaped by these words, not by a vague optimism outside the passage.