Passage
The Lord Jesus Christ [be] with your spirit. Grace [be] with you.
The Lord Jesus Christ [be] with your spirit. Grace [be] with you.
2 Timothy 4:20 Erastus remained in Corinth, but Trophimus I left behind in Miletus sick.
2 Timothy 4:21 Use diligence to come before winter. Eubulus salutes thee, and Pudens, and Linus, and Claudia, and the brethren all.
2 Timothy 4:22 The Lord Jesus Christ [be] with your spirit. Grace [be] with you.
The verse centers on "Spirit", "grace", "lord", "jesus", and "christ". It is saying that salvation is received as God's gift through faith, so boasting is pushed out by the wording itself.
The prior verse says "Use diligence to come before winter Eubulus...", giving immediate footing for "Spirit" and "grace". In 2 Timothy context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "Spirit" and "grace" with trust shaped by these words, not by a vague optimism outside the passage.