Passage
And they, going forth, preached everywhere, the Lord working with [them], and confirming the word by the signs following upon [it].
And they, going forth, preached everywhere, the Lord working with [them], and confirming the word by the signs following upon [it].
Mark 16:18 they shall take up serpents; and if they should drink any deadly thing it shall not injure them; they shall lay hands upon the infirm, and they shall be well.
Mark 16:19 The Lord therefore, after he had spoken to them, was taken up into heaven, and sat at the right hand of God.
Mark 16:20 And they, going forth, preached everywhere, the Lord working with [them], and confirming the word by the signs following upon [it].
The verse centers on "going", "forth", "preached", "everywhere", "lord", "working", "confirming", and "word". It is saying that the verse draws attention to "going" and "forth", so its meaning should be read from those terms before moving to application.
The prior verse says "The Lord therefore after he had spoken...", giving immediate footing for "going" and "forth". In Mark context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "going" and "forth" with trust shaped by these words, not by a vague optimism outside the passage.