Passage
The grace of the Lord Jesus Christ [be] with your spirit. Amen.
The grace of the Lord Jesus Christ [be] with your spirit. Amen.
Philippians 4:21 Salute every saint in Christ Jesus. The brethren who [are] with me salute you.
Philippians 4:22 All the saints salute you, and specially those of the household of Caesar.
Philippians 4:23 The grace of the Lord Jesus Christ [be] with your spirit. Amen.
The verse centers on "Spirit", "grace", "lord", "jesus", "christ", and "amen". It is saying that salvation is received as God's gift through faith, so boasting is pushed out by the wording itself.
The prior verse says "All the saints salute you and specially...", giving immediate footing for "Spirit" and "grace". In Philippians context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "Spirit" and "grace" with trust shaped by these words, not by a vague optimism outside the passage.