Passage
Let not sin therefore reign in your mortal body, so as to obey the lusts thereof.
Let not sin therefore reign in your mortal body, so as to obey the lusts thereof.
Romans 6:10 For in that he died to sin, he died once: but in that he liveth, he liveth unto God.
Romans 6:11 So do you also reckon that you are dead to sin, but alive unto God, in Christ Jesus our Lord.
Romans 6:12 Let not sin therefore reign in your mortal body, so as to obey the lusts thereof.
Romans 6:13 Neither yield ye your members as instruments of iniquity unto sin: but present yourselves to God, as those that are alive from the dead; and your members as instruments of justice unto God.
Romans 6:14 For sin shall not have dominion over you: for you are not under the law, but under grace.
The verse centers on "therefore", "reign", "mortal", "body", "obey", "lusts", and "thereof". It is saying that the verse draws attention to "therefore" and "reign", so its meaning should be read from those terms before moving to application.
The nearby context moves from verse 11's "So do you also reckon that you..." into verse 13's "Neither yield ye your members as instruments...", so "therefore" and "reign" belong inside that flow. In Romans context, the local focus is righteousness by faith, union with Christ, life in the Spirit, and God's covenant faithfulness.
A plain takeaway is to answer the verse's own emphasis on "therefore" and "reign" with trust shaped by these words, not by a vague optimism outside the passage.