Passage
Thou shalt seek them, and shalt not find them, even them that contended with thee: they that war against thee shall be as nothing, and as a thing of nought.
Thou shalt seek them, and shalt not find them, even them that contended with thee: they that war against thee shall be as nothing, and as a thing of nought.
Isaiah 41:10 Fear thou not; for I am with thee: be not dismayed; for I am thy God: I will strengthen thee; yea, I will help thee; yea, I will uphold thee with the right hand of my righteousness.
Isaiah 41:11 Behold, all they that were incensed against thee shall be ashamed and confounded: they shall be as nothing; and they that strive with thee shall perish.
Isaiah 41:12 Thou shalt seek them, and shalt not find them, even them that contended with thee: they that war against thee shall be as nothing, and as a thing of nought.
Isaiah 41:13 For I the LORD thy God will hold thy right hand, saying unto thee, Fear not; I will help thee.
Isaiah 41:14 Fear not, thou worm Jacob, and ye men of Israel; I will help thee, saith the LORD, and thy redeemer, the Holy One of Israel.
The verse centers on "thou", "shalt", "seek", "find", "even", "contended", and "thee". It is saying that the verse draws attention to "thou" and "shalt", so its meaning should be read from those terms before moving to application.
The nearby context moves from verse 11's "Behold all they that were incensed against..." into verse 13's "For I the LORD thy God will...", so "thou" and "shalt" belong inside that flow. In Isaiah context, the local focus is the Holy One of Israel, judgment and restoration, the servant of the LORD, and Zion's hope.
A plain takeaway is to answer the verse's own emphasis on "thou" and "shalt" with trust shaped by these words, not by a vague optimism outside the passage.