Passage
Persecute and destroy them in anger from under the heavens of the LORD.
Persecute and destroy them in anger from under the heavens of the LORD.
Lamentations 3:64 Render unto them a recompence, O LORD, according to the work of their hands.
Lamentations 3:65 Give them sorrow of heart, thy curse unto them.
Lamentations 3:66 Persecute and destroy them in anger from under the heavens of the LORD.
The verse centers on "persecute", "destroy", "anger", "under", "heavens", and "lord". It is saying that the verse draws attention to "persecute" and "destroy", so its meaning should be read from those terms before moving to application.
The prior verse says "Give them sorrow of heart thy curse...", giving immediate footing for "persecute" and "destroy". In Lamentations context, the local focus is covenant, worship, and faithfulness.
A plain takeaway is to answer the verse's own emphasis on "persecute" and "destroy" with trust shaped by these words, not by a vague optimism outside the passage.