Passage
do not despise prophecies,
do not despise prophecies,
1 Thessalonians 5:18 in everything give thanks, for this is God’s will for you in Christ Jesus.
1 Thessalonians 5:19 Do not quench the Spirit;
1 Thessalonians 5:20 do not despise prophecies,
1 Thessalonians 5:21 but examine all things; hold fast to that which is good;
1 Thessalonians 5:22 abstain from every form of evil.
The verse centers on "despise" and "prophecies". It is saying that the verse draws attention to "despise" and "prophecies", so its meaning should be read from those terms before moving to application.
The nearby context moves from verse 19's "Do not quench the Spirit..." into verse 21's "but examine all things hold fast to...", so "despise" and "prophecies" belong inside that flow. In 1 Thessalonians context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "despise" and "prophecies" with trust shaped by these words, not by a vague optimism outside the passage.