Passage
The Lord be with your spirit. Grace be with all of you.
The Lord be with your spirit. Grace be with all of you.
2 Timothy 4:20 Erastus remained at Corinth, but Trophimus I left sick at Miletus.
2 Timothy 4:21 Be diligent to come before winter. Eubulus greets you, also Pudens and Linus and Claudia and all the brothers.
2 Timothy 4:22 The Lord be with your spirit. Grace be with all of you.
The verse centers on "Spirit", "grace", and "lord". It is saying that salvation is received as God's gift through faith, so boasting is pushed out by the wording itself.
The prior verse says "Be diligent to come before winter Eubulus...", giving immediate footing for "Spirit" and "grace". In 2 Timothy context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "Spirit" and "grace" with trust shaped by these words, not by a vague optimism outside the passage.