Passage
You will pursue them in anger and destroy them From under the heavens of Yahweh!
Lamentations 3:66 (LSB)
Nearby Context
Lamentations 3:64 You will recompense them, O Yahweh, According to the work of their hands.
Lamentations 3:65 You will give them dullness of heart; Your curse will be on them.
Lamentations 3:66 You will pursue them in anger and destroy them From under the heavens of Yahweh!
Study Lenses
The verse centers on "pursue", "anger", "destroy", "under", "heavens", and "yahweh". It is saying that the verse draws attention to "pursue" and "anger", so its meaning should be read from those terms before moving to application.
The prior verse says "You will give them dullness of heart...", giving immediate footing for "pursue" and "anger". In Lamentations context, the local focus is covenant, worship, and faithfulness.
A plain takeaway is to answer the verse's own emphasis on "pursue" and "anger" with trust shaped by these words, not by a vague optimism outside the passage.