And they went out and preached everywhere, while the Lord worked with them, and confirmed the word by the signs that followed.] [And they promptly reported all these instructions to Peter and his companions. And after that, Jesus Himself sent out through them from east to west the sacred and imperishable preaching of eternal salvation.]
Mark 16:18 and they will pick up serpents, and if they drink any deadly poison, it will not hurt them; they will lay hands on the sick, and they will recover.”
Mark 16:19 So then, the Lord Jesus, after He had spoken to them, was taken up into heaven and sat down at the right hand of God.
Mark 16:20 And they went out and preached everywhere, while the Lord worked with them, and confirmed the word by the signs that followed.] [And they promptly reported all these instructions to Peter and his companions. And after that, Jesus Himself sent out through them from east to west the sacred and imperishable preaching of eternal salvation.]
The verse centers on "went", "preached", "everywhere", "lord", "worked", "confirmed", "word", and "signs". It is saying that the verse draws attention to "went" and "preached", so its meaning should be read from those terms before moving to application.
The prior verse says "So then the Lord Jesus after He...", giving immediate footing for "went" and "preached". In Mark context, the local focus is Christ, faith, and discipleship.
A plain takeaway is to answer the verse's own emphasis on "went" and "preached" with trust shaped by these words, not by a vague optimism outside the passage.