Passage
Therefore I will profane the princes of the sanctuary; and I will make Jacob a curse, and Israel an insult.”
Therefore I will profane the princes of the sanctuary; and I will make Jacob a curse, and Israel an insult.”
Isaiah 43:26 Put me in remembrance. Let us plead together. Declare your case, that you may be justified.
Isaiah 43:27 Your first father sinned, and your teachers have transgressed against me.
Isaiah 43:28 Therefore I will profane the princes of the sanctuary; and I will make Jacob a curse, and Israel an insult.”
The verse centers on "therefore", "profane", "princes", "sanctuary", "make", "jacob", "curse", and "israel". It is saying that the verse draws attention to "therefore" and "profane", so its meaning should be read from those terms before moving to application.
The prior verse says "Your first father sinned and your teachers...", giving immediate footing for "therefore" and "profane". In Isaiah context, the local focus is the Holy One of Israel, judgment and restoration, the servant of the LORD, and Zion's hope.
A plain takeaway is to answer the verse's own emphasis on "therefore" and "profane" with trust shaped by these words, not by a vague optimism outside the passage.