Passage
Lo, ye <FI>are<Fi> of nothing, and your work of nought, An abomination--it fixeth on you.
Lo, ye <FI>are<Fi> of nothing, and your work of nought, An abomination--it fixeth on you.
Isaiah 41:22 They bring nigh, and declare to us that which doth happen, The first things--what they <FI>are<Fi> declare ye, And we set our heart, and know their latter end, Or the coming things cause us to hear.
Isaiah 41:23 Declare the things that are coming hereafter, And we know that ye <FI>are<Fi> gods, Yea, ye may do good or do evil, And we look around and see <FI>it<Fi> together.
Isaiah 41:24 Lo, ye <FI>are<Fi> of nothing, and your work of nought, An abomination--it fixeth on you.
Isaiah 41:25 I have stirred up <FI>one<Fi> from the north, And he cometh, From the rising of the sun he calleth in My name, And he cometh in <FI>on<Fi> prefects as <FI>on<Fi> clay, And as a potter treadeth down mire.
Isaiah 41:26 Who hath declared from the first, and we know? And beforetime, and we say, `Righteous?' yea, there is none declaring, Yea, there is none proclaiming, Yea, there is none hearing your sayings.
The verse centers on "nothing", "nought", "abomination--it", and "fixeth". It is saying that the verse draws attention to "nothing" and "nought", so its meaning should be read from those terms before moving to application.
The nearby context moves from verse 23's "Declare the things that are coming hereafter..." into verse 25's "I have stirred up FI one Fi...", so "nothing" and "nought" belong inside that flow. In Isaiah context, the local focus is the Holy One of Israel, judgment and restoration, the servant of the LORD, and Zion's hope.
A plain takeaway is to answer the verse's own emphasis on "nothing" and "nought" with trust shaped by these words, not by a vague optimism outside the passage.